Heterogeneous presentation of giant prolactinoma

Atypical Presentation of Giant Prolactinoma: Case Report and Review of

Background: Prolactin is a well-known hormone that mainly functions as a milk producer. Its secretion by lactotroph cells in the pituitary gland (anterior pituitary) is under regulation by different effectors, mainly by Dopamine. However, under non-physiologic circumstances, Prolactin can be over secreted (hyper-prolactinemia) either due to primary (such as pituitary adenoma) or secondary (such...

Obstructive Hydrocephalus, Fifth Nerve and Hypothalamus Involvement: Acute Presentation of a Giant Prolactinoma

INTRODUCTION Pituitary tumors from lactotrope cells account for about 40% of all functioning pituitary cancers. Men tend to present with a larger, more invasive and rapid growth prolactinomas than women, possibly because hypogonadism features are less evident. CASE REPORT A 27-year-old, previously asymptomatic Saudi man presented with a 3-day history of emesis with severe left-sided frontal h...

Delayed presentation of late-onset cerebrospinal fluid rhinorrhoea following dopamine agonist therapy for giant prolactinoma

UNLABELLED Therapeutic shrinkage of prolactinomas with dopamine agonists achieves clinical benefit but can expose fistulae that have arisen as a result of bony erosion of the sella floor and anterior skull base by the invasive tumour, resulting in the potential development of cerebrospinal fluid (CSF) rhinorrhoea, meningitis, and rarely pneumocephalus. Onset of symptoms is typically within 4 mo...

Cabergoline Treatment in Invasive Giant Prolactinoma

Patients with invasive giant prolactinoma suffer from a constellation of symptoms including headache, blurred vision, lethargy, and sexual dysfunction. Cabergoline, a potent dopamine agonist, is a known medication prescribed for the treatment of invasive giant prolactinoma. Here, we report a case of invasive giant prolactinoma in a 52-year-old Saudi male with dramatic response to cabergoline tr...

Giant Palmar Lipoma: A Rare Presentation